Abstract
The purpose of this study was to examine the acute diuretic effect of the water extract of the aerial parts of Retama raetam (RR) at a dose of 5 mg/kg/h in normal rats. The aqueous extract was administered intravenously and the diuresis was followed within 4 h after starting the treatment. Intravenous administration of the aqueous RR extract produced a significant increment on diuresis from the second hour ( p < 0.01) to the fourth hour ( p < 0.001). Furosemide at a dose of 0.1 mg/kg/h had a similar effect when compared to RR administration. Parallel, the noticed increase of diuresis was associated with an elevation of glomerular filtration rate ( p < 0.05) and a significant decrease of urinary osmolarity ( p < 0.001). However, RR extract did not affect plasma urea levels, urine pH, plasma osmolarity and hematocrite. It is then concluded that the water extract of the aerial parts of RR exhibited a significant diuretic effect in normal rat.
Published Version
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