Abstract
The cardio protective action of cilostazol, milrinone and their combination effect on myocardial infarction induced by isoproterenol subjected to Wistar rats was done by studying various parameters - heart rate, % infarct size change, LDH level, CPKMB level, ECG pattern. In the following research work effect of synthetic drugs cilostazol, milrinone and their combined effect were studied over various biochemical and cardiac parameters. Isoproterenol was used in inducing myocardial infarction to Wistar rats. Isoproterenol (15 mg/100g) administration, causes an increased levels of biochemical markers-lactate dehydrogenase (2546.25±1.38), creatine phosphokinase (1485.5±.80) in serum of rats indicating potential action of isoproterenol on myocardium. Due to necrosis of myocardium a marked increase of these enzymes was seen in blood. A significant decrease in heart rate (262±.96) in isoproterenol treated rats was observed. Infarct size in ISO group rats (41%±.008) increased to certain extent with promiscuous yellow colored non-viable cells visible indicating infarction. Statistical analysis done by one-way ANOVA followed by the Dunnett's multiple comparison test where ISO control group compared with other groups, p value < 0.001 indicating extremely significant results. The present study demonstrated pharmacological benefits of combination dose of cilostazol, milrinone as evidenced by improvement in heart rate, Lactate dehydrogenase level, Creatine phosphokinase MB level, Electrocardiogram pattern, % infarct size.
Highlights
In terms of global burden of disease in 1999, the world health organization placed myocardial infarction in sixth place and stroke at seventh place, but by 2020 they will have moved to first and fourth place respectively [1]
Standardization of isoproterenol was done in Wistar rats; it was found that the animals showed mortality at dose of 25 mg ISO concentration administered according to body weight of Wistar rats ranging in between 200-250 Gms
Myocardial infarction was determined by various biochemical parameters - lactate dehydrogenase, creatine phosphokinase, heart rate, % infarct size in myocardium of rat heart
Summary
In terms of global burden of disease in 1999, the world health organization placed myocardial infarction in sixth place and stroke at seventh place, but by 2020 they will have moved to first and fourth place respectively [1]. Myocardial infarction is the irreversible damage of myocardial tissue caused by prolonged ischemia and hypoxia. This most commonly occurs when a coronary artery becomes occluded following the rupture of an atherosclerotic plaque, which leads to the formation of a blood clot. Myocardial infarctions produce clinical symptoms that include intense chest pain, substernal heaviness, squeezing, shortness of breath, fatigue, fainting, nausea, sweating, anxiety, sleeplessness, hypertension or hypotension (depending in part on the extent of cardiac damage), tachycardia and arrhythmias [3]
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