Abstract
In this paper, pH sensitive carboxymethyl cellulose (CMC) beads were proposed as a protective capsule for layered double hydroxides-drug (LDH-Drug) nanohybrids in gastrointestinal tract conditions. Cephalexin (CPX), as a model drug, was intercalated between LDH layers through co-precipitation method. The resulting nanohybrid (LDH-CPX) was used to prepare nanocomposite hydrogel beads by association with carboxymethyl cellulose. The synthesized products were characterized using FTIR, XRD and SEM analysis. In vitro drug delivery tests were carried out in conditions simulating the gastrointestinal tract to prove the effectiveness of these novel nanocomposite beads as a controlled drug delivery system. The drug release tests revealed a better protection against stomach pH and a controlled liberation in the intestinal tract conditions for CMC encapsulated LDH-CPX nanohybrids.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
