Abstract
It has been shown that the glucose-grown cells of Brucella abortus, Strain 19, will oxidize the known intermediates of the tricarboxylic acid cycle. The oxidation of citric acid, α-ketoglutaric acid, and succinic acid by whole cells is a function of pH. Experiments with sonic extracts have demonstrated that this pH dependence can be attributed to permeaability phenomena. Arsenite ion and sodium fluoroacetate inhibit the oxidation of several substrates. Under suitable conditions large amounts of citric acid accumulate when known intermediates of the Krebs cycle are oxidized in the presence of sodium fluoroacetate. The evidence cited is compatible with the existence of the tricarboxylic acid cycle in Br. abortus, Strain 19. Also, the data show that the organism is capable of oxidizing carbohydrates by this pathway without adaptation.
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