Abstract
Tissue glycogen levels, some glycolytic enzymes of liver and muscle and liver glycogen synthetase have been studied in rats fed a high fat-high cholesterol (hypercholesterolaemic) diet, and compared with those rats fed a normal diet. Blood glucose, 1 h after a glucose load, was higher in rats fed the hypercholesterolaemic diet. Glycogen levels in liver and muscle were significantly decreased, but less so in kidney and aorta. Hepatic hexokinase activity decreased by 31% in the hypercholesterolaemic rats. Phosphorylase activity in liver and muscle also decreased (47.5 and 30.8% respectively), but phosphoglucomutase activity was not affected. Hepatic glucose-6-phosphatase activity alightly decreased, while hepatic fructose diphosphate aldolase very significantly decreased (68%). On the other hand, liver phosphoglucoisomerase activity increased in the hypercholesterolaemic rats. Hepatic glycogen synthetase activity considerably decreased.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
