Abstract
Neuroimmunology and Neuroinflammation is an open access journal, with focuses on neuroimmunology and neuroinflammation research, and coverage extending to other basic and clinical studies related to neuroscience.
Highlights
The immune system plays many roles in cancer prevention
It is understood that the immune system can impact the immunogenicity of the tumor itself given intact immune systems impact the very nature of the tumor and contribute to its ability to progress and grow
Another challenge is that gliomas appear to have natural mechanisms to inhibit T cell activation and decrease peripheral T-cell counts, resulting in the lymphopenia seen in these patients even prior to the initiation of therapy[6]
Summary
The immune system plays many roles in cancer prevention. does it protect against viral infections and the development of virus-driven tumors, it eliminates tumor cells, and rapidly identifies and. Tumor specific mutations are less common in brain tumors compared to other malignancies, and may be unique to each individual, requiring optimal individualized medicine which can be cost-prohibitive[5] Another challenge is that gliomas appear to have natural mechanisms to inhibit T cell activation and decrease peripheral T-cell counts, resulting in the lymphopenia seen in these patients even prior to the initiation of therapy[6]. TILs have unique anti-tumor properties as they are extracted from tumor biopsies where they have been exposed and conditioned to the tumor microenvironment These cells can be isolated from tumor tissue and expanded in IL-2 cytokine prior to re-introduction and have shown to be an effective approach for patients with metastatic malignant melanoma[12]. Both TILs and CTLs, once infused back into the patient, recognize tumor associated antigens (TAA) via their TCR as antigeneic peptides presented by MHC,
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