Abstract
Abstract Introduction The deprivation of blood supply to an intestinal segment, followed by its subsequent restoration, triggers the condition known as intestinal ischaemia-reperfusion syndrome (i-IRI). Throughout this process, proinflammatory and oxidative mediators are produced, released, and distributed via the bloodstream, ultimately causing damage both locally and systemically. Cannabidiol (CBD) is a molecule with antioxidant and anti-inflammatory properties that regulate oxidative stress and inflammatory states. The aim of this study is to evaluate the therapeutic potential of CBD in a model of i-IRI in aged rats. Methods Thirty-six 12-month-old male WAG/RijHsd rats were used, divided into three groups: healthy control group (control), untreated i-IRI group (i-IRI), and CBD-treated i-IRI group (CBD). CBD (10 mg/kg) was administered via the femoral route 30 minutes before reperfusion. Blood samples and intestinal biopsies were taken from six animals in each group, while the other six animals underwent the D-xylose absorption test to evaluate intestinal absorptive function. Results Treatment with CBD significantly reduced the degree of histological injury (DHI) compared to the untreated group (1.78 ± 1.23 vs. 4.5 ± 0.56; p<0.001). It also improved intestinal absorptive function (control group: 2.08 ± 0.16; untreated: 0.96 ± 0.06; CBD: 1.74 ± 0.06 µg/mL; p<0.001). Conclusion The administration of CBD prior to the restoration of the ischaemic insult was effective in reducing damage to the intestinal mucosa and improving absorptive capacity.
Published Version
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