Abstract
Calmodulin participates in the regulation of the synthesis, metabolism and action of cyclic AMP, the second messenger in the function of certain dopamine receptors located in striatum. The content of calmodulin bound to striatal membranes increases during supersensitivity elicited by dopamine receptor blockade or by cocaine. In contrast, calmodulin content decreases during desensitization elicited by amphetamine or persistent stimulation of dopamine receptors by the agonist.
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