Abstract
The potentiation of apomorphine-induced hypermotility by systemically or intra-raphe administered LSD was accompanied by a decreased synthesis and release of 5-HT and an increased synthesis of DA in the nucleus accumbens. Haloperidol behaved like a competitive dopaminolytic antagonist without anti-5-HT properties. Clozapine similar to 5-HT antagonists counteracted the potentiation effect and the decreased release of 5-HT following systemic and intra-raphe injections. Opposite changes in DA release by systemically and intra-raphe administered LSD revealed directly and indirectly induced effects. The increase in DA release was abolished by haloperidol and clozapine.
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