Abstract
Chemodynamic therapy (CDT) has been widely studied for antitumor application. Herein, CoFe-layered double hydroxides (CoFe-LDH) were fabricated by a coprecipitation method and followed by calcination treatment at 250 °C (LDH-250) and 500 °C (LDH-500). After thermal treatment, oxides content has increased gradually and the metal valence state changes which endow them photothermal and chemodynamic properties. Among them, LDH-250 possesses a considerable peroxidase-like catalytic activity at pH = 6.5 with Michaelis-Menten constant (KM) of 0.24 mM and maximum velocity (Vmax) of 4.00 × 10−8 M s−1. Besides, LDH-250 and LDH-500 exhibit good photothermal effects and the solution temperature could be elevated to 55.7 °C and 57.9 °C under irradiation with 808 nm laser for 10 min. In addition, the 4T1 cells and bacteria cultured with LDH-250 and LDH-500 were killed completely when exposed to NIR irradiation. In general, CoFe-LDH with thermal treatment shows enhanced Fenton catalytic ability and photothermal property which exhibits great potential for antibacterial and antitumor applications with good cytocompatibility.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call