Đặc điểm một số chỉ số tế bào máu ngoại vi và Ferritin huyết thanh ở người bệnh Thalassemia sau điều trị thải sắt bằng Deferiprone tại Bệnh viện đa khoa Mộc Châu năm 2023

Abstract

Objective: Evaluate changes in some peripheral blood cell indices and serum Ferritin in Thalassemia patients after iron chelation treatment with Deferiprone at Moc Chau general Hospital in 2023; Methods: Cross-sectional, retrospective study. 44 patients with Thalassemia treated at Moc Chau general Hospital in 2023; Results: The average age of disease was 11 ± 12.05 years old. The rate of carrying genes for β-Thalassemia and α-Thalassemia was 97.73% and 2.27%, respectively. The Thai ethnic group had the highest rate of disease (70.45%), followed by Muong (20.45%), Xinh mun (4.55) and Dao (4.55%). The patients had moderate anemia with small and hypochromic red blood cells. After 5 days of treatment with Deferiprone, RBC, HGB, MCV, MCH, MCHC and RDW-CV% indices increased, however it returned to its original state after 3 months of treatment. Furthermore, after 5 days and 3 months of treatment with Deferiprone, WBC, MON, and PLT indices were within normal limits; NEUT slightly decreased; and LYM increased. In particularly, compared to the time of admission (1365.5±243.6 ng/ml), after 5 days of treatment with Deferiprone, serum Ferritin slightly increased (1373.5±236.3 ng/ml) and after 3 months decreased (1281.5±229.03 ng/ml); Conclusion: The patients of Thalassemia have a moderate response to Deferiprone. Keywords: Thalassemia, Ferritin, Peripheral blood cells, Moc Chau, Deferiprone.