Butorphanol plus propofol for analgesia in painless visible artificial abortion

Abstract

Objective To study the efficacy and safety of butorphanol plus propofol for anesthesia in painless visible artificial abortion.Methods In May 2011,120 pregnant women who voluntarily received painless artificial abortion in our department were randomly assigned to be treated with 0.02 mg/kg butorphanol (butorphanol group,n=60) and fentanyl (fentanyl group,n=60) at 5 min prior to induced anesthesia using propofol,which were then supplemented via venous pumps during the surgery for maintenance anesthesia.The efficacy and adverse reactions were compared.Results The difference in analgesic effect was unremarkable between both groups (P＞0.05).Compared with fentanyl for anesthesia,a reduced dose was noted for butorphanol [(139.0± 12.0) vs (170.0± 18.5)mg,P＜0.05],thus resulting in minor respiratory inhibition and markedly reduced incidence of bucking (all P＜0.05).Patients treated with butorphanol yielded a shorter duration to recovery of consciousness compared with those receiving fentanyl (P＜0.05).No adverse reaction or complication was documented.Conclusion Butorphanol plus propofol has better efficacy of anesthesia in painless visible artificial abortion without adverse reactions. Key words: Butorphanol; Fentanyl; Propofol; Abortion, induced; Respiratory,insufficiency