Year-end Sale % OFF 
Abstract
Breast carcinoma rarely occurs in cases of foreign body granulomas following liquid silicone injection. Although the Food and Drug Administration (FDA) banned the use of all silicone injection products in 1992, liquid silicone injection for breast augmentation continues to be performed illegally. We herein report a case of breast carcinoma following liquid silicone injection in a 67-year-old female.A total of 45 years after liquid silicone injection, the patient had felt a breast mass in the right breast. Mammography showed a smooth mass that retracted the right nipple. Due to the presence of a marked acoustic shadow caused by the granulomas, evaluating the mass on ultrasonography was difficult. However, magnetic resonance imaging (MRI) showed a lobulated mass under the right nipple. The mass exhibited low signal intensity (SI) on T1-weighted images and intermingled high and low SI on T2-weighted images. Heterogeneous early enhancement with central low intensity was noted on dynamic contrast-enhanced MRI. Several oval-shaped low SI structures in the adipose tissue and disruption of the pectoralis major muscle were also observed. We diagnosed the patient with invasive ductal carcinoma based on a stereotactic-guided Mammotome® (a vacuum-assisted biopsy system manufactured by DEVICOR MEDICAL JAPAN, Tokyo, Japan) biopsy and subsequently performed mastectomy and axillary lymph node dissection (with a positive result for the sentinel node biopsy). Histologically, invasive ductal carcinoma was observed in the silicone granuloma.The development of foreign body granulomas following breast augmentation usually makes it difficult to detect breast cancer; thus, various devices are required to confirm the histological diagnosis of breast lesions. The stereotactic-guided Mammotome® biopsy system may be an effective device for diagnosing breast cancer developing in the augmented breast.
Highlights
Liquid silicone injection for breast augmentation was initiated worldwide and in Japan in the 1940s [1,2]
We investigated available approaches for diagnosing this tumor histologically and performed a stereotactic-guided Mammotome® biopsy because the tumor was clearly detectable on mammography
Stromal invasion of invasive ductal carcinoma was observed in the silicone granuloma (Figure 4b,c), and inflammatory granulomas and foreign body giant cells were observed (Figure 4d)
Summary
Liquid silicone injection for breast augmentation was initiated worldwide and in Japan in the 1940s [1,2]. The FDA has never approved the use of injections of liquid silicone for cosmetic treatment in patients. Case presentation A 67-year-old female felt a breast mass in her right breast and visited our hospital She had received silicone oil injection into bilateral breasts at 22 years of age. Mammography showed a smooth mass that retracted the right nipple (Figure 1a). T1-weighted images showed a low signal intensity (SI) mass (3.5 × 3.2 × 4.0 cm in size) that retracted the right nipple (Figure 2a). According to the histological findings of the biopsied specimens, we diagnosed the patient with invasive ductal carcinoma and subsequently performed mastectomy and axillary lymph node dissection (with a positive result for the sentinel node biopsy). Four cycles of treatment with EC (90 mg/m2 of epirubicin and 600 mg/m2 of cyclophosphamide) were given as adjuvant chemotherapy, and the patient currently remains alive, without recurrence, at 10 months after the surgery
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
