Abstract
There are limited data on the efficacy of mesenchymal stem cells (MSCs) in models of extensive hepatic resection. In the previous issue of Stem Cell Research &Therapy, Yu and colleagues demonstrate that transient hypoxic preconditioning of MSCs improves their efficacy in a rat model of massive hepatectomy. This effect appears to be mediated, in part, by increased vascular endothelial growth factor (VEGF) production by the preconditioned MSCs as well as the injured liver. Neutralizing VEGF antibodies ameliorated the benefit of hypoxia-preconditioned MSCs, establishing VEGF as a key mediator of their benefit. This novel approach merits further exploration both mechanistically and to establish the functional advantages of MSCs in other injury settings.
Highlights
There are limited data on the efficacy of mesenchymal stem cells (MSCs) in models of extensive hepatic resection
The study by Yu and colleagues [1] in the previous issue of Stem Cell Research & Therapy investigated the biological effects of hypoxia-preconditioned bone marrowderived mesenchymal stem cells (HP-MSCs) and their utility in a rat model of massive hepatectomy
The authors demonstrate that administration of conventionally cultured bone marrow-derived MSCs into the hepatectomy model resulted in increased percentages of proliferating cell nuclear antigen (PCNA)-positive cells and cyclin D1 levels in the liver but did not affect serum albumin levels, liver-to-body weight ratio (LBWR), or survival rates of the rats
Summary
There are limited data on the efficacy of mesenchymal stem cells (MSCs) in models of extensive hepatic resection. The study by Yu and colleagues [1] in the previous issue of Stem Cell Research & Therapy investigated the biological effects of hypoxia-preconditioned bone marrowderived mesenchymal stem cells (HP-MSCs) and their utility in a rat model of massive hepatectomy.
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