Abstract
BackgroundOxidative stress plays a crucial role in the pathophysiology of acute ischemic stroke. Thioredoxin exists and released from cells during inflammation and oxidative stress and was recognized as an oxidative-stress marker.ObjectiveThe objective of this study was to assess the role of thioredoxin as an oxidative stress biomarker in diagnosis and prognosis of acute ischemic stroke in a sample of patients recruited from Beni-Suef Governorate, north Upper Egypt.MethodsA case control study included 100 subjects; 50 patients with first-ever acute ischemic stroke presented within 24 h from the onset and 50 healthy volunteers as a control. Clinical, functional, and radiological evaluation was done for the patients, and all patients and control were subjected to routine laboratory tests and assessment of serum level of thioredoxin by solid-phase sandwich enzyme-linked immunosorbent assay.ResultsThioredoxin was significantly higher in acute stroke patients compared to control group (p value = 0.001). Thioredoxin level was significantly higher in hypertensive patients (p value = 0.007), patients who had carotid stenosis ≥50% (p value = 0.001), patients with poor outcome (p value = 0.009), and in patients with cardio-embolic stroke (p value = 0.001).Significant positive correlation was found between thioredoxin level and volume of infarction (r = 0.501 and p = 0.001), stroke severity at presentation (r = 0.503 and p = 0.021) and clinical outcome after 3 months (r = 0.551 and p value = 0.001).ConclusionThioredoxin as a marker of oxidative stress can be used as a new diagnostic and prognostic blood biomarker for stroke.
Highlights
Acute ischemic stroke carries an enormous health burden, since it is rated to be one of the main causes of disability and even mortality [1]
This study is a case control study conducted in neurology department, Beni-Suef University during the period from June to December 2018 and included 100 subjects; 50 patients with first-ever acute ischemic stroke presented within 24 h from the onset and 50 healthy volunteers who do not have a family history of stroke matched in age and sex to stroke patients as a control
According to the resulting Modified Rankin Scale (mRS) score after 3 months, 33 (66%) patients were classified as having good outcome and 17 (34%) patients were with poor outcome
Summary
Acute ischemic stroke carries an enormous health burden, since it is rated to be one of the main causes of disability and even mortality [1]. In the last few years, there has been a considerable evidence to suggest that oxidative stress associated with excessive production of reactive oxygen species (ROS) is a primary and fundamental mechanism of ischemic. The brain is more vulnerable to oxidative damage due to various factors that enhance the formation of reactive species: high oxygen consumption, high fat content of unsaturated fatty acids, and high iron levels in some brain regions. Thioredoxin is a ubiquitous small protein (12 KDa) which has a redox-active. Oxidative stress plays a crucial role in the pathophysiology of acute ischemic stroke. Thioredoxin exists and released from cells during inflammation and oxidative stress and was recognized as an oxidative-stress marker
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