Abstract
The aim of this work was to investigate preventive effect of dexmedetomidine combined with sevoflurane on neurological disorders in liver cancer patients during postoperative recovery under the ultrasound image restoration (UIR) algorithm. A blind deconvolution medical UIR algorithm was established in this study. The patients anesthetized with sevoflurane for liver cancer surgery were rolled into an experimental group (group A) (dexmedetomidine treatment before surgery) and a control group (group B) (normal saline treatment before surgery). They were monitored routinely before, during, and after surgery, and immune and liver functions of patients were observed before and after surgery. Besides, their cognitive function and adverse reactions were assessed after surgery. Results showed that patients from group A had smaller fluctuation in average arterial blood pressure and heart rate, but their bispectral index (BIS) increased obviously after surgery in contrast to those of group B ( P < 0.05 ). Moreover, changes of immune and liver functions in patients from group A decreased sharply compared with group B ( P < 0.05 ). The postoperative minimental state examination (MoCA) score of patients from group A was 27.51 ± 2.02, while the score of group B was 25.79 ± 2.35. The postoperative (MoCA) score of group A was markedly higher than the score of group B, and the difference was statistically obvious ( P < 0.05 ). Besides, the incidence of postoperative cognitive dysfunction (POCD) in patients from group A and B was 12.91% and 32.26% in turn. The incidence of POCD in patients from group A was sharply lower than the incidence of group B ( P < 0.05 ). In addition, the total incidence of adverse reactions in patients from group A was 6.45%, which was significantly lower than the 22.58% of group B, and the difference was statistically substantial ( P < 0.05 ). In summary, dexmedetomidine combined with sevoflurane could effectively reduce POCD and promote systemic circulation recovery, which had clinical application value.
Highlights
Liver cancer is a malignant tumor of the liver, which can be divided into primary and secondary liver cancers
All subjects and their families had signed the informed consent forms, and all patients were rolled into two groups. e patients from both groups were anesthetized with sevoflurane during surgery. e patients from group A were given with a dose of dexmedetomidine hydrochloride with 1 μg/kg before anesthesia, while patients from group B were treated with the same dose of normal saline
Comparison on Abdominal Ultrasound Images of Liver Cancer Patients before and after Restoration Based on Ultrasound Image Restoration Algorithm
Summary
Liver cancer is a malignant tumor of the liver, which can be divided into primary and secondary liver cancers. Primary liver cancer is the most dangerous malignant tumor in the world, mainly including hepatocellular carcinoma. E early onset of liver cancer is relatively insidious, and there is lack of specific symptoms in clinical, so many patients miss the best treatment time. E low concentration of sevoflurane can make the heart, ejection, and contraction rates of patients drop rapidly. It should not be applied in patients with elevated intracranial pressure. Dexmedetomidine is Scientific Programming a kind of α2 adrenergic receptor agonist that is highly selective, which is featured with fast onset, short action, sedation, analgesia, and inhibition of sympathetic nerve activity, stable hemodynamics, less anesthetic dosage, and no respiratory depression. When dexmedetomidine achieves and maintains a sufficient level of sedation, it is easy to wake patients up and can reduce the amount of other sedative drugs. e sedation induced by dexmedetomidine is similar to nonrapid eye movement sleep so that the quality of sleep can be improved, and dexmedetomidine is beneficial to the recovery of the immune system [4,5,6]
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