Abstract
An efficient synthesis of 3,4-dihydropyrimidinones (DHPMs) using bismuth triflate as the catalyst for the first time from an aldehyde, β-keto ester and urea in acetonitrile is described. Compared to the classical Biginelli reaction conditions, this new method consistently has the advantage of excellent yields (58-95%) and short reaction time (1-4 h) at room temperature.
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