Abstract
BackgroundCurcumin and vanillin are the two useful compounds in food and medicine. Bismuth nitrate pentahydrate is an economical and ecofriendly reagent.MethodBismuth nitrate pentahydrate impregnated montmorillonite KSF clay and curcumin were subjected to microwave irradiation.ResultsMicrowave-induced bismuth nitrate-promoted synthesis of vanillin from curcumin has been accomplished in good yield under solvent-free condition. Twenty-five different reaction conditions have been studied to optimize the process.ConclusionThe present procedure for the synthesis of vanillin may find useful application in the area of industrial process development.
Highlights
Curcumin and vanillin are the two useful compounds in food and medicine
In continuation of our research on environmentally benign reactions, we have been working on methodology development using microwave irradiation for many years
We have demonstrated the catalytic activity of trivalent bismuth nitrate pentahydrate in a number of occasions
Summary
A polyphenol derived from Curcuma longa (commonly known as turmeric) is an ancient spice and therapeutic used in India for centuries to induce color in food and to treat a wide array of diseases. It prevents tumor formation in a number of animal models, including models of skin, colon, liver, esophageal, stomach, and breast cancer [5,6,7,8]. Curcumin has demonstrated the ability to improve patient outcomes in Phase I clinical trials [9]. Vanillin (4-hydroxy-3-methoxybenzaldehyde) is an important guaiacol derivative which is extremely selective inhibitor of aldehyde oxidase. We report an easy and extremely rapid one-step method for the preparation of vanillin from naturally occurring curcumin in the presence of bismuth nitrate under microwave irradiation (Figure 1)
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