Abstract
BackgroundHyperlipidemia is a major cause for atherosclerosis which is a frontline cause for mortality in the world. Bisflavonoids are dimeric flavonoids abundant in few medicinal herbs with various pharmacological effects. However, in vivo anti-hyperlipidemic role of bisflavonoids (BFR) is limited. The present investigation is aimed to study BFR from the leaf extract of Araucaria bidwillii Hook. in rat model of hyperlipidemia.ResultsAdministration of HFD was significantly (p < 0.0001) shown to increase total cholesterol (TC), low-density lipoprotein (LDL), and triglycerides (TG) associated with decrease in HDL. BFR at two doses significantly decreased TC, LDL, and TG in HFD-fed rats. In addition, BFR significantly (p < 0.0001) decreased the MDA and significantly (p < 0.0001) increased the impaired anti-oxidant enzyme SOD and CAT in heart tissue induced by HFD. Further, 28 days administration of BFR significantly (p < 0.001) decreased HFD-induced aortic wall thickness.ConclusionIt can be concluded that bisflavonoids from A. bidwillii Hook. leaf extract administered to high fat-fed rats showed beneficial anti-hyperlipidemic effect by reducing lipid profiles and protecting the heart tissue from oxidative stress.
Highlights
Hyperlipidemia is a major cause for atherosclerosis which is a frontline cause for mortality in the world
The evaluation of anti-hyperlipidemic potential of bisflavonoids fraction may have a valueadded biological effect and it may have a source for natural anti-hyperlipidemic and nutraceutical. This present investigation was aimed to investigate the antihyperlipidemic effect of bisflavonoids separated from the plant Araucaria bidwillii Hook., in high-fat diet-induced hyperlipidemia in rats
The results from TLC plate for BFR revealed the presence of various spots with different Rf values
Summary
Hyperlipidemia is a major cause for atherosclerosis which is a frontline cause for mortality in the world. The present investigation is aimed to study BFR from the leaf extract of Araucaria bidwillii Hook. Hyperlipidemia is a condition in which there is an elevated level of lipids and lipoproteins in the blood It is a frontline major cause for atherosclerosis associated with morbidity and mortality in Asian countries [1]. Our previous investigation on bisflavonoids separated from the ethyl acetate fraction has shown neuroprotective effect through anti-oxidant mechanism in rat model of oxidative stress [19]. The evaluation of anti-hyperlipidemic potential of bisflavonoids fraction may have a valueadded biological effect and it may have a source for natural anti-hyperlipidemic and nutraceutical This present investigation was aimed to investigate the antihyperlipidemic effect of bisflavonoids separated from the plant Araucaria bidwillii Hook., in high-fat diet-induced hyperlipidemia in rats
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