Biomimetic Nanoparticles for Cancer Targeting and Drug Delivery

Abstract

0Cellular membrane engineered nanoparticles (NPs) have shown immense potential for anti-cancer drug delivery applications. In principle, cell membrane of any type of cells can be processed to obtain purified cellular membrane which can self-assemble to form stable and highly robust nanovesicles. These nanovesicles retain lipid-bilayer architecture of host’s cells and much of the surface biomarkers and proteins are conserved during top-down approach. Interestingly, nanovesicles have exhibited long plasma circulation and appreciable tumour specific binding, which is largely suggestive of their biomimetic properties. Many pioneer studies have demonstrated their ability to encapsulate different chemotherapeutic agents and photosensitizers of varied chemical complexities, and releasing them in a triggered fashion. Additionally, the novel NPs system has been developed for cancer immunotherapy. The review discusses some of the important research and applications of cellular membrane derived nanovesicles for different forms of cancer therapy and their potential to be developed as personalized nanomedicine.