Abstract
Ferroptosis, as a recently discovered non-apoptotic programmed cell death with an iron-dependent form, has attracted great attention in the field of cancer nanomedicine. However, many ferroptosis-related nano-inducers encountered unexpected limitations such as immune exposure, low circulation time, and ineffective tumor targeting. Biomimetic nanomaterials possess some unique physicochemical properties which can achieve immune escape and effective tumor targeting. Especially, certain components of biomimetic nanomaterials can further enhance ferroptosis. Therefore, this review will provide a comprehensive overview on recent developments of biomimetic nanomaterials in ferroptosis-related cancer nanomedicine. First, the definition and character of ferroptosis and its current applications associated with chemotherapy, radiotherapy, and immunotherapy for enhancing cancer theranostics were briefly discussed. Subsequently, the advantages and limitations of some representative biomimetic nanomedicines, including biomembranes, proteins, amino acids, polyunsaturated fatty acids, and biomineralization-based ferroptosis nano-inducers, were further spotlighted. This review would therefore help the spectrum of advanced and novice researchers who are interested in this area to quickly zoom in the essential information and glean some provoking ideas to advance this subfield in cancer nanomedicine.
Highlights
The Severe Problems in Treating Cancer and the Requirement of a New ApplicationFrom the report of the American Cancer Society, except cardiovascular diseases, tumors have become the second cause of death (Cortes et al, 2020)
This review mainly summarized the latest developments of biomimetic nanomaterials in the field of the development trends of ferroptosis-related tumor treatment and some considerations about the principles, advantages, and limitations of these bionic strategies
The fluorescence intensity of Arg-rich manganese silicate nanobubble (AMSN) was stronger than that of the control group, and it was proportional to the concentration and the incubation time. These results indicated that ferroptosis plays a crucial role in AMSN-induced cell death
Summary
Xinyu Zhang 1, Yanling Ma 2, Jipeng Wan 3, Jia Yuan 3, Diqing Wang 3, Weiyi Wang 3, Xiao Sun 3* and Qingwei Meng 1*. Ferroptosis, as a recently discovered non-apoptotic programmed cell death with an irondependent form, has attracted great attention in the field of cancer nanomedicine. Many ferroptosis-related nano-inducers encountered unexpected limitations such as immune exposure, low circulation time, and ineffective tumor targeting. Biomimetic nanomaterials possess some unique physicochemical properties which can achieve immune escape and effective tumor targeting. Certain components of biomimetic nanomaterials can further enhance ferroptosis. This review will provide a comprehensive overview on recent developments of biomimetic nanomaterials in ferroptosis-related cancer nanomedicine. The definition and character of ferroptosis and its current applications associated with chemotherapy, radiotherapy, and immunotherapy for enhancing cancer theranostics were briefly discussed. The advantages and limitations of some representative biomimetic nanomedicines, including biomembranes, proteins, amino acids, polyunsaturated fatty acids, and biomineralization-based ferroptosis nano-inducers, were further spotlighted.
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