Abstract
The purpose of scientific research was to study the effect of the developed biologically active drug «Stimulin» on the level of superovulatory treatment with PMSG «Folligon» and the quantitative yield of the number of transferable embryos. The experiments were conducted on donor cows of the Ukrainian Black-and-White breed. Experimental donor cows were intramuscular administration injected for 8, 9, 10, 11 days of the oestrous cycle by drug «Stimulin» in a single dose 20 ml. Control animals in these days were similarly administered 20 ml of physiological saline solution. It was established that, when gonadotropin PMSG “Folligon” of a polyovulatory reaction in donor cows, receiving an intramuscular administration of the drug "Stimulin" dose of 20 ml from day 8 to 11 after estrus , promotes a positive trend until its level and the number of embryos suitable for transplantation increase (by 28,5 %), and also reduces neovulated follicles by 27,5%. With induction of gonadotrophin PMSG“Folligon” by superovulation in donor cows, receiving an intramuscular administration from day 8 to day 11 after estrus of the drug "Stimulin", contributes to the tendency to increase the level of superovulation and the number of transferable embryos and reduces the number of non-ovulated follicles.
Highlights
Transfer embryos is an important method of accelerated reproduction of valuable genetic resources that contributes to the qualitative improvement of Авторські права захищені | Creative Commons Attribution 4.0 International LicenseSECTION VIII
It has been established that the embryo quantity and quality obtained are due to the large variability in ovarian follicular response, the basis of which is the large population of antral follicles in donor cows ovaries during the induce of their growth by exogenous gonadotropins
The pregnant mare serum gonadotrophin (PMSG) is one of the gonadotropic hormone used for the induction of superovulation
Summary
The efficacy of induced superovulation is related to the age and animals individual ability, feeding and keeping conditions, the intensity of exchange processes in their body, lactation stage and hormonal status, period of year, stress, nature of parturition and postpartum periods, with gonadotrophin preparation type, its biological activity, batch and total dose, duration and timing of treatment, and the use of additional hormones in the superovulatory scheme [1,2,3,4,5,6]. The pregnant mare serum gonadotrophin (PMSG) is one of the gonadotropic hormone used for the induction of superovulation The preparations of this gonadotropins group are injected once to the donors, which is valuable because it reduces the labor cost of veterinary treatment of animals. The purpose of scientific research was to study the effect of the developed biologically active drug «Stimulin» on the level of superovulatory treatment with PMSG «Folligon» and the quantitative yield of the number of transferable embryos
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