Biological studies of novel 22-Membered N2O2 diazadioxa Macrocyclic Bis-Triazoles transition metal Complexes: Synthesis and physicochemical studies

Abstract

Transition metal complexes of Co(II), Ni(II) & Cu(II) with bistriazole based Schiff bases derived from the condensation of 1,6-bis(2-formylphenyl) hexane and bis-(4-amino-5-mercapto-1,2,4-triazole-3-yl) alkanes. The Schiff bases and their Co(II), Ni(II) & Cu(II) complexes characterized with the help of elemental analysis, conductance measurements, magnetic measurements, FTIR, 1H NMR, FAB-mass studies. Antibacterial assay of the synthesized ligands SL-I to SL-IV and its metal complexes is investigated across Staphylococcus aureus, Escherichia coli and Bacillus Subtilis. The Schiff base SL-IV and copper complexes showed impressive antibacterial activity against Staphylococcus aureus. Antioxidant assay of the bistriazole based N2O2 Schiff bases (SL-I to SL-II) & its metal complexes was analyzed by using the 2, 2-diphenyl-1-picrylhydrazyl radical (DPPH). The SL-II, SL-III and copper (II) complexes were found to be having maximum antioxidant property against ascorbic acid. The metal complexes exhibit very good anthelmintic assay compared to its Schiff bases and standard drug used for the comparison study was Piper zine citrate.