Abstract
The biological and physicochemical properties of cultures of two isogenic recombinant variants of Y. pseudotuberculosis were studied. The cell genomes of the studied cultures differed only with respect to the presence or absence of the fra operon responsible for capsule formation in Y. pestis. The expression of the above-mentioned trait is amplified by an increase in the cultivation temperature of microbial biomass and stimulates a decrease in the viability and adaptation potential of bacteria in vitro. In a warm-blooded host organism, the capsule-forming recombinant variant is characterized by greater residual pathogenicity and immunogenicity to the experimental plague strains of laboratory animals as compared to the reference variant cells. These differences can be attributed to the more increased colonizing ability of the capsule-forming microbes caused by the resistance of the host cells to phagocytosis.
Published Version
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