Abstract
Abstract The research work aims at developing a real-time non-invasive metabolism and blood circulation surveillance system for monitoring human’s health condition by sensing the various bio-signals on the human body. Our goal is to use the developed system to study the functions and characters of organs and tissues that highly relate with the metabolism and blood circulation system, and also, it is expected to help modeling the entire circulation system. At phase I of the research, in this paper we focus on developing a new low-cost, portable, high-accuracy, non-invasive radial pulse sensor. Inspired by touch capability and related biomechanical advantage of human fingertip, the mechanical design of the sensor mimics the physiological structure of human fingertip. The biomimetic sensor is then well calibrated using a high-accuracy force sensor, and the model is accurately identified by the system identification method. Further the calibrated sensor is applied to diagnose the arterial stiffness by measuring the augmentation index (AI) which is the important biomarker of vascular aging. Preliminary results demonstrate the sensor performance that it is capable of non-invasively, accurately, and reliably measuring radial pulse signals at real time, as well as to quantitatively determine the vessel aging.
Highlights
Cardiovascular system is built by central and systemic circulation systems, which generates the blood flow by the heart and transmits the blood to the whole body through the vessel pathway [1]
The results demonstrate the good measurement performance of the developed sensor as its raw data is very close to the calibrated data, as well as the detail of the pulse information is well revealed
Clinic application and results Next to the achieved accurate radial pulse signals using the sensor, one clinical application based on the radial pulse measurement is extensionally presented
Summary
Cardiovascular system is built by central and systemic circulation systems, which generates the blood flow by the heart and transmits the blood to the whole body through the vessel pathway [1]. Associated with the blood flow, the pulse is an important signal containing the pathological information like heart function, blood flow resistance, vessel wall elastic, and blood viscosity. These pathological changes are usually expressed on strength, frequency, altitude, and waveform variation of the pulse signal. Instead of invasive thermodilution methods and complicated noninvasive impedance-cardiography, the pulse wave analysis can be an alternative way to monitor the cardiovascular system. One of these pulses is the radial pulse. In prospect of the increase in demand, developing a low-cost, wearable pulse sensor that can offer real-time continuous monitoring, immunizes mechanical and electronic noises, as well as displays some basic diagnostic results is becoming one of the most popular research topics in this area [5,6]
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