Abstract
Changes in lung bioelectric impedance were revealed in male Wistar rats exposed chronically to doxorubicin. Bioimpedance measurements were performed in rats two months after the first injection of doxorubicin (a cumulative dose of 10 mg/kg divided into 4 injections for 4 weeks) or saline. Bioimpedance was analysed at multiple frequencies (10, 30, 70 and 150 kHz) of electric current. Electrodes were placed on the surface of the lung. Significantly lower absolute values of the reactance and phase angle of bioelectrical impedance of the myocardium, liver (noted by us earlier) and lung in rats treated with doxorubicin compared with control animals indicated toxic damage to organs. Significantly higher amplitude (at a frequency of 70 kHz) of bioelectrical impedance of the rat’s lung may be associated with emphysematous changes and inflammation in the lung in the group with chronic exposure to doxorubicin compared to the rats in the control group.
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