Abstract
The Bio-C Sealer is a recently developed high-plasticity, calcium-silicate-based, ready-to-use material. In the present study, chemical elements of the materials were characterized using scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR). The biocompatibility of the Bio-C Sealer was investigated using cytotoxicity tests and histological responses in the roots of dogs’ teeth. XRD, SEM, and FTIR produced hydrated calcium silicate in the presence of water molecules. In addition, FTIR showed the formation of calcium hydroxide and polyethylene glycol, a dispersing agent. The 1:4 dilutions of Bio-C Sealer presented weaker cytotoxicity than the Calcipex II in an in vitro system using the V-79 cell line. After 90 d, the periradicular tissue response of beagle dog roots was histologically evaluated. Absence of periradicular inflammation was reported in 17 of the 18 roots assessed with the Bio-C Sealer, whereas mature vertical periodontal ligament fibers were observed in the apical root ends filled with the Bio-C Sealer. Based on these results and previous investigations, the Bio-C Sealer is recommended as an effective root-end filling material. These results are relevant for clinicians considering the use of Bio-C Sealer for treating their patients.
Highlights
Calcium hydroxide (Ca(OH)2 ) is an inorganic compound commonly used in dentistry; it has become one of the most widely accepted materials in dental clinics [1]
There are very few premixed materials available for use in endodontic treatment, and we considered it reasonable to compare Bio-C Sealer and Calcipex II because both are premixed, Ca(OH)2 -based endodontic materials
The X-ray diffraction (XRD) patterns of the clinker suggested that the mineral phase was composed largely of dicalcium silicate (C2 S), tricalcium silicate (C3 S), tricalcium aluminate (C3 A), and zirconium oxide (ZrO2 ) as the contrast agent (Table 1) [19,20,21]
Summary
Calcium hydroxide (Ca(OH)2 ) is an inorganic compound commonly used in dentistry; it has become one of the most widely accepted materials in dental clinics [1]. Materials 2020, 13, 4770 original tissues when in contact with periradicular tissues [4] It is mainly composed of dicalcium and tricalcium silicates with unique properties and a hydraulic self-curing material that makes it suitable for clinical use [5,6,7,8,9]. A single-cone technique with a hydraulic calcium silicate-based sealer may represent a good tool given the superior flowability of the material and its ability to slightly expand upon setting [10,11]. Elizabeth et al [10] evaluated the outcome of nonsurgical root canal treatments using a single-cone technique and a hydraulic calcium silicate-based sealer.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
