BIOCHEMICAL MARKERS OF HYPERANDROGENISM IN CONDITIONS OF INCREASED EXPOSURE OF MANGANESE AND NICKEL

Abstract

The etiology of polycystic ovaries syndrome (PCOS) may be associated with high levels of exposure manganese and nickel. These trace elements can change the metabolism of androgensObjectives. Determination of biochemical markers of hyperandrogenism in women with PCOS in conditions with elevated levels of manganese and nickel.Methods. 43 women with PCOS were examined. The control group consisted of 27 healthy women of reproductive age. In serum, using chemiluminescent immunoassay method were determined the total (TT) and free (TF) testosterone, dehydroepiandrosterone sulfate (DHEA-S), 17-hydroxyprogesterone (17-HOP), dihydrotestosterone (DHT), Sex hormone-binding globulin (SHBG) and calculated Free Androgen Index (FAI).Results. In 16.27% of women with PCOS hyperandrogenism was not observed. Detected increased levels of TT (36.59%), TF (30%), DHEA-S (36.59%) 17 - HOP (56.41%), DHT (62.5%), FAI (3.85 %). There was only one increase of androgen 17-HOP (15,38%), TT (7.32%), DHT (6.25%) and DHEA-S (2.44%).Conclusions. Elevated levels of manganese and nickel cause accumulation of metabolites of testosterone in the body. Diagnostics of biochemical hyperandrogenism should be based on determination 17-HOP, TT and perhaps DHT.