Abstract
The purpose of this study was to analyze the oxidative stress level and inflammatory status of saliva in the presence of certain materials used for obtaining interim prosthetic restorations. Four types of interim resin materials were investigated: a pressure/heat-cured acrylic resin (Superpont C+B, SpofaDental a.s Czech Republic, /KaVo Kerr Group), a milled resin (Telio CAD polymethyl methacrylate, Ivoclar Vivadent AG, Liechtenstein), a 3D printed resin (NextDent C&B MFH, NextDent by 3D Systems, the Netherlands), and a pressure/heat-cured micro-filled indirect composite resin (SR Chromasit, Ivoclar Vivadent AG, Liechtenstein). The disk-shaped resin samples (30 mm diameter, 2 mm high) were obtained in line with the producers’ recommendations. The resulting resin specimens were incubated with saliva samples collected from twenty healthy volunteers. In order to analyze the antioxidant activity of the tested materials, certain salivary parameters were evaluated before and after incubation: uric acid, gamma glutamyl transferase (GGT), oxidative stress responsive kinase-1 (OXSR-1), and total antioxidant capacity (TAC); the salivary levels of tumor necrosis factor (TNFα) and interleukin-6 (IL-6) (inflammatory markers) were measured as well. The obtained results are overall favorable, showing that the tested materials did not cause significant changes in the salivary oxidative stress level and did not influence the inflammatory salivary status.
Highlights
Interim prosthetic restorations are essential for obtaining a predictable and personalized final prosthetic outcome; this type of restoration has alternatively been referred to as “provisional”, “temporary”, or “transitional” restoration
The present study investigates aspects related to the biochemical interactions between saliva and different interim prosthetic materials: a pressure/heatcured acrylic resin (Superpont C+B, SpofaDental a.s., Jicin, Czech Republic, KaVo Kerr Group), a milled resin (Telio CAD polymethyl methacrylate, Ivoclar Vivadent AG, Schaan, Liechtenstein), a 3D printed resin (NextDent C&B MFH, NextDent by 3D Systems, Soesterberg the Netherlands), and a pressure/heat-cured micro-filled indirect composite resin
The analysis of the interaction between the materials designated for fabricating interim prosthetic restorations and the salivary environment consisted of evaluating their antioxidant activity by determining the value of certain parameters: salivary redox biomarkers (uric acid, gamma glutamyl transferase (GGT), oxidative stress responsive kinase-1 (OXSR-1), and total antioxidant capacity (TAC)) and the influence of these materials on the inflammatory salivary status, assessed by determining the levels of tumor necrosis factor (TNFα) and interleukin 6 (IL-6)
Summary
Interim prosthetic restorations are essential for obtaining a predictable and personalized final prosthetic outcome; this type of restoration has alternatively been referred to as “provisional”, “temporary”, or “transitional” restoration. Interim prosthetic restorations represent veritable “instruments”, playing an important role in the dental-maxillary apparatus adaptation and reshaping, especially in the complex oral rehabilitation cases associated with their extended use. This is due to the fact that interim prosthetic restorations allow for the testing of different functional parameters, facilitate and guide the healing process of peri-implant gingival tissue, and contribute to the healing and reshaping of periodontal tissues. It is imperative that the materials from which the interim restorations are obtained should prove, first of all, to have very good biocompatibility [1,2,3]
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