Abstract
Bidensoviruses, which are non-enveloped spherical particles 20−24 nm in diameter, possess two single-stranded DNA genome segments in separate capsids. Bombyx mori bidensovirus (BmBDV) is a virus in the Bombyx mori bidensovirus species which is the sole and type species of the genus Bidensovirus. BmBDV replicates mainly in silkworm midgut columnar cells and causes the fatal flacherie disease. Bidensoviruses have unique properties different from the densoviruses in the family Parvoviridae, such as the bipartite structure, encoding its own DNA polymerase B, the chronic pathology and its turbulent evolutionary history. So far, BmBDV is the only virus member of the Bidnaviridae and little is known about its replication mechanisms.
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