Abstract
ABSTRACTIntroduction: We have been exploring the effects of dihydroprogesterone in female amygdala-kindled rats. For intraperitoneal (i.p.) time–response studies, we used a vehicle containing the common solvent, benzyl alcohol (BnOH). The vehicle containing BnOH was also tested alone as a control.Method and Results: Unexpectedly, it was found that the vehicle containing BnOH had clear-cut anti-seizure effects in the kindling model, with an ED50 of 100 mg/kg. In a follow-up study, dose- and time–response studies of i.p. BnOH were done in male mice in the maximal pentylenetetrazol (PTZ) model. BnOH suppressed PTZ seizures in a dose-dependent manner, with an ED50 of 300 mg/kg against hindlimb tonic extension. Effects were fully established at 5-min post injection and lasted for an hour.Conclusion: BnOH is not an inert solvent. It has clear-cut anti-seizure effects against both focal and generalized seizures.
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