Abstract

目的 比较贝那普利与依那普利治疗老年轻、中度高血压的疗效和安全性.方法将116例社区老年轻、中度高血压病患者随机、单盲分为两组,其中贝那普利组58例,依那普利组58例,治疗8周,并从两组随机抽20例于治疗前及治疗8周末行24 h动态血压检测.结果治疗8周后,两组药物均能有效的降低血压,有效率贝那普利组为94.82%,依那普利组为84.48%,组间比较差异无显著意义(P>0.05).贝那普利组的谷/峰值收缩压为60.5%,舒张压为57.7%;依那普利组分别为55.2%和52.9%.不良反应发生率贝那普利组为10.34%,依那普利组为18.79%,差异有显著意义(P<0.05).结论贝那普利更适合社区老年轻、中度高血压病的治疗。

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