Abstract
1. The effect of endotoxin (1μg/kg i.v.) on the phagocytic activity of the reticulo-endothelial system (carbon-clearance test) has been studied in mice. There were two peaks of stimulation, 3 and 24 h after application. A high weight of the spleen was only seen at the second peak. 2. Following cyclophosphamide (300 mg/kg i.V.), an initial increase in phagocytic activity (12 h) gave way to a subsequent long-lasting suppression, accompanied by a marked weight loss of the spleen. 3. In mice treated with cyclophosphamide the phagocytic activity could be stimulated by endotoxin, but not to a degree achieved by endotoxin in untreated animals. Reduction of spleen weight by cyclophosphamide could not be reversed by endotoxin. 4. Polyvinylpyridin-N-oxide (100 mg/kg i.v.)-an antisilicotic agent-stimulated phagocytic activity. This effect was transitory and disappeared within 8 days. We therefore assume that the long-lasting antisilicotic action cannot be mediated by elevated phagocytosis. 5. Injection of polyvinylpyridin-N-oxide did not protect animals from the cytotoxic action of cyclophosphamide.
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