Abstract
Pyrroloquinoline and guanidine-derived alkaloids present distinct groups of marine secondary metabolites with structural diversity that displayed potentialities in biological research. A considerable number of these molecular architectures had been recorded from marine sponges belonging to different marine genera, including Batzella, Crambe, Monanchora, Clathria, Ptilocaulis and New Caledonian starfishes Fromia monilis and Celerina heffernani. In this review, we aim to comprehensively cover the chemodiversity and the bioactivities landmarks centered around the chemical constituents exclusively isolated from these three marine genera including Batzella, Crambe and Monanchora over the period 1981–2017, paying a special attention to the polycyclic guanidinic compounds and their proposed biomimetic landmarks. It is concluded that these marine sponge genera represent a rich source of novel compounds with potential applications for cancer and other therapeutic areas.
Highlights
As a result of the rise of many current medical challenges, including hepatitis, parasitic infection, lifestyle-induced diseases, such as diabetes, hypertension, many forms of cancer, multi-drug resistance pathogens and other diseases, searching for new bioactive compounds with novel modes of action is necessary
Monanchora and for Batzella sponges producedarchitectures, pyrroloquinoline some deep-water species of Batzella produced pyrroloquinoline-derived alkaloids, which raises alkaloids is taxonomically unrelated to the Batzella previously mentioned
We provide comprehensive insights on the previous chemical and biological reports isolated natural compounds are classified by their polycyclic skeleton coupled with their recorded for the metabolites of the three marine genera
Summary
As a result of the rise of many current medical challenges, including hepatitis, parasitic infection, lifestyle-induced diseases, such as diabetes, hypertension, many forms of cancer, multi-drug resistance pathogens and other diseases, searching for new bioactive compounds with novel modes of action is necessary. HIV-1 inhibitors [13,14], enzyme inhibitors [15], receptor antagonist [16], Ca2+ channel blocker [17], relatedness of this genus (family Chondropsidae) to other genera like Crambe and Monanchora antifungal [18] and antimicrobial [19,20,21] These interesting compounds are considered taxonomic (family Crambeidae). Pyrroloquinoline some deep-water species of Batzella produced pyrroloquinoline-derived alkaloids, which raises alkaloids is taxonomically unrelated to the Batzella previously mentioned It is almost a chemotaxonomic question about the systematic relatedness of this genus (family Chondropsidae) to similar to the Zyzzya and Latrunculia marine sponges but their phylogenetic relationship is still other genera like Crambe and Monanchora (family Crambeidae).
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call