Abstract
Abstract A basement membrane could not be demonstrated with any degree of consistency in specimens of human cervix by means of the Ritter-Oleson staining technique, even though this technique demonstrated the membrane satisfactorily in control sections of normal breast and kidney tissue. The use of the term “basement membrane” and associated phrases such as “extension through” and “disruption of” in describing criteria for diagnosing invasive uterine cervical carcinoma is ill-advised. From our study, the existence of a basement membrane in the human cervix is more apparent than real. The criteria for distinguishing in situ from invasive carcinoma in the cervix should be the same as those used for such a distinction in any other organ. The Ritter-Oleson stain seems to have no practical value in facilitating this differentiation.
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