Baixo estado de atividade da doença e avaliação de dano permanente em pacientes ambulatoriais com lúpus eritematoso sistêmico

Abstract

ObjectiveVerify the association between low disease activity and damage accrual in Systemic Lupus Erythematosus patients.MethodsWe evaluated 60 patients following the Rheumatology Out patient Clinic with American College of Rheumatology and European League Against Rheumatism of Systemic Lupus Erythematosus diagnostic criteria. We evaluated clinical and demographic data like gender, age, and disease duration. We evaluated disease activity using the Systemic Lupus Erythematosus Low disease activity score, and damage accrual we evaluated using the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index for systemic lupus erythematosus. The Chi-Square test realized statistical analysis, and a level of 0.05 was considered significant.ResultsOn 60 patients studied, we found lupus low disease activity state in 45 (75%) and 15 (25%) were in disease activity. Concerning damage accrual, we found that 11 (42.3%) had damage, and 40 (66,6%) did not have damage. Five patients with damage did not have disease activity, and 40 with no activity did not have damage. Of patients with disease activity, 11 we found with damage, and no damage was found in nine. Females predominate in this population with 98.3% of patients; the mean age was 43.4 years old, and the mean disease duration was 12.8 years. The statistical analysis results showed an association between low disease activity and no damage accrual in SLE patients (p<0.005).ConclusionOur results demonstrated an association between low disease activity and no damage accrual in systemic lupus erythematosus patients.