Abstract
A novel automated procedure for analysis of solid samples based on the on-line dissolution of solid sample and sugaring-out reagent in water-acetonitrile mixture coupled with sugaring-out homogenous liquid-liquid extraction was developed. The procedure was performed in a mixing chamber of a stepwise injection analysis manifold. The performance of the suggested approach was demonstrated by the determination of 2,4-dichlorobenzyl alcohol, amylmetacresol, Yellow Orange S, Azo Rubine and Ponceau 4R in pharmaceutical samples. After phase separation, the upper acetonitrile phase containing 2,4-dichlorobenzyl alcohol, amylmetacresol and lower aqueous phase containing artificial dyes were sequentially analyzed. Under optimal experimental conditions the linear ranges were found to be 0.1–10mgL−1 for 2,4 dichlorobenzyl alcohol, 0.5–50mgL−1 for amylmetacresol, and 1–100mgL−1 for artificial dyes. The sample throughput was 10h−1. The proposed method was successfully applied for the automated analysis of commercial throat lozenges and the analytical results agreed fairly well with the results obtained by reference HPLC-UV method.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
