Abstract
Antibodies to serotonin in serum were investigated by ELISA in patients with paranoid schizophrenia ( N=27), schizoaffective psychosis ( N=38), depression ( N=67), Alzheimer's disease ( N=21), chronic alcoholism ( N=43), rheumatoid arthritis ( N=25), and multiple sclerosis ( N=16), and in healthy volunteers ( N=60). Increased antibody reactivity to serotonin was found in schizoaffective psychosis, chronic alcoholism, and rheumatoid arthritis. Decreased antibody reactivity to serotonin was found in multiple sclerosis and depression. These anti-serotonin antibodies belong to the class of so-called natural autoantibodies. Alterations of these natural autoantibodies could indicate a disturbance to the immune system. It is possible that these antibodies could also influence receptor function. Autoantibodies to neurotransmitters in a wide spectrum of psychiatric disorders have not previously been reported.
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