Abstract
Heartworm infection caused by Dirofilaria immitis induces a devastating disease that greatly affects the global canine population. The mechanism leading to heartworm pathology has been attributed to be mostly by mechanical damage of the worm to the dog´s vascular system and immune-mediated, but the latter processes are not completely understood. Autoantibodies targeting host molecules such as lipids and nucleic acids have been described with pathological roles during malaria and COVID-19 and mediating anemia and thrombocytopenia. We hypothesized that autoantibodies could be present and have a pathological role during canine heartworm disease caused by D. immitis. In this study, we analyzed the levels of autoantibodies (IgM and IgG) against membrane lipid phosphatidylserine (PS) and DNA in the serum of 169 canine samples based on D. immitis infection. First, our results found significant levels of anti-PS IgM and IgG autoantibodies that were associated with D. immitis-positive when compared to D. immitis-negative samples. Second, we found that autoantibodies, particularly anti-PS, are correlated with hematological parameters such as low platelet count suggesting an association with pathologies such as thrombocytopenia. Altogether, these findings elucidate the understudied presence and pathological role of autoantibodies during canine heartworm disease by D. immitis with implications as biomarkers of disease.
Published Version
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