Abstract
Auricular Transcutaneous Vagus Nerve Stimulation may Increase the Risk of Mild-COVID-19 Infection or of Herpetic Flare: Is there a Role of Microbiota?
Highlights
One labial herpetic flare was observed in the non-compliant auricular transcutaneous vagus nerve stimulation (ATVNS) group (p
ATVNS may increase the risk of clinical expression of COVID-19 or of herpes labialis
Since the autonomic nervous system may influence positively mucosal inflammation and negatively the propagation of viruses, we investigated whether auricular transcutaneous vagus nerve stimulation decreased or increased the risk of COVID-19 or of labial herpetic flare
Summary
SARS-CoV-2 is a neurotropic virus leading to pleiotropic neurological symptoms [1,2,3,4]. Vagus nerves may be involved [5]. The vagal nerve is a classical pathway to access to the central nervous system for herpes viruses [6,7,8,9], prions [10,11] or abnormal proteins like alpha-synuclein [12,13,14,15] or tau [16]. The vagal autonomic pathway may be at the crossroad of neurotropic viral diseases and tauopathies/prionopathies [17]. SARS-CoV-2 can reach the central nervous system through the vagal nerve.
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