Abstract
In the current study, we used an environmentally friendly method called pulsed laser irradiation for the preparation of AuNPs and hydroxyapatite NPs alone and as a composite nanomaterials. The optical, morphology, and chemical bonding possessions of prepared AuNPs, hydroxyapatite NPs, and Au-hydroxyapatite composites were studied using different techniques like Transmission Electron Microscopy (TEM), Ultraviolet–visible Spectram (UV–VIS), and Fourier transform infrared spectroscopy (FTIR). The anticancer activity of prepared Au NPs, hydroxyapatite NPs, and Au-hydroxyapatite composites against prostate cancer cell line (PC-3 cells) was evaluated by MTT assay as well the possible mechanisms underlying the induction of apoptosis. The consequences suggest that the nanoparticles can act against an antiproliferative agent against PC-3 cells-induced apoptosis by activating caspase-8 and reducing the NF-κB translocation pathway. The current study demonstrates the potential role of an Au-hydroxyapatite composite for anticancer applications via the activation of the apoptosis pathway through extrinsic and intrinsic pathways.
Published Version
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