Abstract
Until the work of Trost and Schroeder (J. Am. Chem. Soc. 1999, 121, 6759), transition-metal-catalyzed asymmetric allylic alkylation (AAA) reactions were confined to the use of ‘soft’, stabilized carbanions. However, general methods to apply carboxylic acid carbanions in AAA reactions remain undeveloped. As a large step forward, the authors report the use of acyclic amides as nucleophiles in the Pd-catalyzed AAA reaction with 1,1′-P,N ferrocene ligand L1. Alkylation of a variety of α-substituted aliphatic and aromatic amides proceeded in high yield with good to high levels of asymmetric induction.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
