Abstract
Abstract This study investigated the effects of pretreatment with antioxidants, kaempferol, and zinc gluconate on serum biochemical changes and impairment in body weight gain following noise-exposure in Wistar rats. Thirty-five animals were evenly grouped into five cohorts: Groups II, III, IV, and V were exposed to noise stress, induced by exposing rats to 100 dB (4 hr/day) for 15 days, from days 33 to 48 after starting the drug treatments. Treatment with kaempferol and/or zinc mitigated noise-induced deficits in body weight gain, and levels of serum lipid and protein fractions. The combined treatment significantly (p < .05) decreased malondialdehyde concentration in kaempferol + zinc gluconate treated group, compared to the group administered deionized water + noise. This result demonstrates that biochemical dyshomeostasis and lipid peroxidation may be involved in the molecular mechanism underlying noise stress and the assortment of kaempferol and zinc gluconate produced an improved mitigating outcome in Wistar rats.
Highlights
A remarkable rise in the reports of noise-associated health perturbations, especially in metropolitan environments with high level of industrialization have been documented in several recent studies (GBD 2019 Hearing Loss Collaborators, 2021)
Our objective was to determine the changes in body weight gain and biochemical parameters in Wistar rats administered with kaempferol and zinc gluconate and exposed to ambient noise of approximately 100 dB
The lowest concentration of glucose was obtained in the group treated with deionized water only (75.21 Æ 2.4 mg/dl), whereas the group treated with DW þ N had the highest concentration (104.31 Æ 31 mg/dl)
Summary
A remarkable rise in the reports of noise-associated health perturbations, especially in metropolitan environments with high level of industrialization have been documented in several recent studies (GBD 2019 Hearing Loss Collaborators, 2021). Continuous subjection to loud noise has been shown to impair growth and significantly decrease the weight of some vital organs in the exposed animals (Jalali et al, 2012). Noise exposure has been shown to trigger alteration in serum biochemical parameters, DNA damage, and loss of neuronal function (Akefe et al, 2020; Ji et al, 2019). Antioxidant assortment has been suggested to yield synergistic effects in treating different conditions (Yasuno et al, 2012), no study is yet to evaluate the effects of combining both metal and flavonoid antioxidants in ameliorating noiseinduced deficits in body weight gain and biochemical imbalances in Wistar rats
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