Abstract
The aim of the study was to investigate the effect ofco-administration of ascorbic acid and zinc gluconate, which are antioxidantnutrients on brain biochemical changes in wistar rats, exposed to the hot-humidseason. Fourteen adult male Wistar rats weighing 110 g - 186 g, were dividedinto two groups of seven rats each. The first group, which served as thecontrol was given distilled water (1 ml/kg); rats in the second group served asthe experimental animals and were first given ascorbic acid (100 mg/kg) andimmediately followed by the administration of zinc (50 mg/kg). The regimenswere given once daily and orally by gavage for a period of 28 days. The dry andwet-bulb temperature values were taken; and from the values, relative humidityand heat index was calculated. The rats were sacrificed on day 29 of theadministration and evaluated for brain catalase, superoxide dismutase andacetylcholinesterase activities. Lipid peroxidation was determined by measuringthe malondialdehyde concentration in the brain. The heat index wassignificantly (P 0.05) of both groups. There were nosignificant differences in activities of superoxide dismutase, catalase andacetylcholinesterase in the brain showed no significant difference (P >0.05) between the groups. In conclusion, the moderate heat stress during thehot-humid season induced brain biochemical changes in Wistar rats, attenuatedby co-administration of ascorbic acid and zinc gluconate. Key Words: heat stress, zinc gluconate, ascorbic acid, catalase, acetylcholinesterase, malondialdehyde.
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