Abstract
BackgroundSeveral meta-analyses have demonstrated that the rs662 polymorphism in Paraoxonase 1 gene (PON1) gene is associated with coronary heart disease (CHD). However, it is still uncertain whether this polymorphism is associated with the plasma levels of oxidized low-density lipoprotein (Ox-LDL) and lipids. This meta-analysis is aimed to clarify the relationships between the rs662 polymorphism and plasma levels of Ox-LDL and lipids.MethodsBy searching in PubMed, Google Scholar, Web of Science, Cochrane Library, Wanfang, VIP and CNKI databases, 5 studies (1369 subjects) and 85 studies (46,740 subjects) were respectively identified for Ox-LDL association analysis and lipid association analysis. Standardized mean difference (SMD) was used to estimate the effects of the rs662 polymorphism on plasma Ox-LDL and lipid levels.ResultsThe carriers of the variant R allele had higher levels of Ox-LDL (SMD = 0.23, 95% CI = 0.10–0.36, P < 0.01), triglyceride (TG) (SMD = 0.06, 95% CI = 0.01–0.11, P = 0.02), total cholesterol (TC) (SMD = 0.04, 95% CI = 0.00–0.07, P = 0.05) and low-density lipoprotein cholesterol (LDL-C) (SMD = 0.04, 95% CI = 0.00–0.08, P = 0.04) than the non-carriers.ConclusionsThis meta-analysis suggests that the association between the PON1 rs662 polymorphism and CHD may partly be mediated by abnormal Ox-LDL and lipid levels caused by the R allele.
Highlights
Coronary heart disease (CHD) is currently the leading cause of death in developed and some developing countries like China [1]
PON1 Paraoxonase 1 gene, Standardized mean difference (SMD) standardized mean difference, 95% CI 95% confidence interval, HWE Hardy-Weinberg equilibrium, TG triglyceride, TC total cholesterol, LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, CHD coronary heart disease, Type 2 diabetes mellitus (T2DM) type 2 diabetes mellitus
We found that the R allele of the rs662 polymorphism is significantly associated with increased levels of oxidized low-density lipoprotein (Ox-LDL), TG, TC and LDL-C, but there is no effect of the rs662 polymorphism on HDL-C was observed
Summary
Coronary heart disease (CHD) is currently the leading cause of death in developed and some developing countries like China [1]. CHD is a multifactorial disease with a number of risk factors being identified in the past few decades. Among these risk factors, the increase in circulating oxidized low-density lipoprotein (Ox-LDL) and dyslipidemia were widely reported with regard to their important roles in the occurrence and development of CHD [2, 3]. Several meta-analyses have demonstrated that the rs662 polymorphism in Paraoxonase 1 gene (PON1) gene is associated with coronary heart disease (CHD). It is still uncertain whether this polymorphism is associated with the plasma levels of oxidized low-density lipoprotein (Ox-LDL) and lipids. This meta-analysis is aimed to clarify the relationships between the rs662 polymorphism and plasma levels of Ox-LDL and lipids
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