Analysis of the correlation and diagnostic value of serum visfatin, hs-CRP and TNF-α in patients with different types of angina pectoris

Abstract

Objective To explore the correlation and diagnostic value of serum visfatin (visfatin), high sensitive C reactive protein (hs-CRP) and tumor necrosis factor-α (TNF-α) in patients with different types of angina pectoris. Methods Eighty-four patients with angina pectoris who were treated in the Eighth hospital of Wuhan from January 2013 to December 2016 were selected as the research subjects, the patients were divided into stable angina pectoris (SAP) group with 39 cases and unstable angina pectoris (UAP) group with 45 cases according to the classification criteria of angina pectoris, Thirty-seven healthy volunteers in the outpatient department of the same period were selected as the control group.To compare the levels of serum visfatin, hs-CRP and TNF-alpha in three groups, analyze the correlation between the levels of serum visfatin and hs-CRP and TNF-alpha levels in patients with angina pectoris, and analyze the diagnostic value of the levels of serum visfatin, hs-CRP, TNF-α and plasma oxidized low density lipoprotein (Ox-LDL) by ROC curve. Results There were no significant differences in fasting blood glucose, uric acid, creatinine, total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) among the three groups (all P>0.05). The systolic pressure (SBP) was (134.27±11.96)mmHg and diastolic pressure (DBP) was (84.23±7.15)mmHg in SAP group, the SBP was (135.98±12.33)mmHg and DBP was (84.47±7.22)mmHg in UAP group, which were all higher than SBP ((121.49±9.97)mmHg )and DBP( (77.38±6.94)mmHg) in the control group (all P 0.05). The level of visfatin in UAP group was (6.57±1.36)μg/L, which was higher than that in SAP group( (4.62±1.08)μg/L) and in control group( (4.27±1.03)μg/L) (all P 0.05). The level of serum hs-CRP, TNF-α and plasma Ox-LDL were (12.38±2.63) mg/L, (4.35±0.28) ng/L and (617.32±53.48) μg/L in UAP group, and the level of serum hs-CRP, TNF-α and plasma Ox-LDL were (8.29±1.74) mg/L, (1.82±0.34)ng/L and (418.57±43.85)μg/L in SAP group, which were higher than hs-CRP (4.06±1.52) mg/L, TNF-α (0.98±0.13)ng/L, Ox-LDL (213.64±32.83)μg/L in control group(all P 0.05). The serum visfatin level was positively correlated with serum hs-CRP, TNF-alpha level and plasma Ox-LDL level in SAP group.(r=0.687, 0.634, 0.656, all P<0.05). The serum visfatin level was positively correlated with the serum hs-CRP, TNF-a level and Ox-LDL level in UAP group (r=0.721, 0.652, 0.673, all P<0.05). ROC curve analysis showed that the levels of serum visfatin, hs-CRP, TNF-α and plasma Ox-LDL were all near 0.7, and the sensitivity and specificity were all above 0.6 identification of different types of angina pectoris. Conclusion The level of serum visfatin in patients with UAP was significantly higher than that of SAP patients, its level is related to serum hs-CRP, TNF- alpha and plasma Ox-LDL levels, the four indexes have a certain predictive value for different types of angina pectoris, and can provide reference for different types of angina. Key words: Stable angina pectoris; Unstable angina pectoris; Visfatin; High sensitive C reactive protein; Tumor necrosis factorα