Relationship between intravascular ultrasound imaging features and soluble serum CD105 level in patients with different coronary lesions

Abstract

Objective To assess the relationship between the level of serum soluble CD105 and the morphology of plaques examined by intravaseular ultrasound (IVUS) in the patients with stable angina (SA) and unstable angina (UA). Methods 127 patients suspected as having coronary heart disease (CHD) underwent coronary artery angiography (CAG) and then divided into 3 groups according to the CAG results:stable angina (SA) group (n =50), unstable angina (UA) group (n =47), and control group (n =30).Peripheral blood samples were collected and serum soluble CD105 was measured by ELISA. 31 patients from the SA group and 31patients from the UA group underwent IVUS. Results The patients of the SA group mainly had fibrous plaques, while the patients of the UA group mainly had unstable and soft lipid plaques.Calcific plaques were found in the SA group ( 12% ) as well as in the UA group with no statistical difference (18.0%, P=0.08). The eccentric index (EI) of the UA group was 0.82±0.55, significantly higher than that of the SA group (0.54±0.23, P＜0.05 ). The serum soluble CD105 level of the UA group was (4.06±0.19 ) μg/L, significantly higher than that of the control group and SA group [ ( 2.57±0. 54)μg/L and (3.47±0.17) μg/L respectively, both P＜0.05 ], and serum soluble CD105 level of the SA group was significantly higher than that of the control group too ( P＜0.05). The concentration of soluble CD105 in vulnerable plaque group was (4.01±0.18 )μg/L, significantly higher than that of the stable plaque group [ (3.22±0.16 ) μg/L, P＜0.01 ]. Conclusion The serum soluble CD105 level of the UA group is significantly higher than those of the patients with SA and those without CHD. The level of soluble CD105may reflect the instability of CHD as well as the vulnerability of plaques. Key words: Angina pectoris ; Vitrasonography, interventional; Soulable CD105