Abstract
A cohort of 287 patients with rheumatoid arthritis (RA) showed that molecular variants (minor T allele and homozygous TT genotype) of the STAT4 rs7574865 polymorphic locus increase the risk of RA development and impact the clinical characteristics of pathological process. Specifically, these variants are associated with high disease activity (р = 0.0023) and III-IV roentgenologic stages of the disease, as well as with grade 2 functional impairment in RA patients in case of disease duration more than 5 years. The revealed association of molecular variants of the studied STAT4 rs7574865 locus with clinical RA characteristics indicates that STAT4 rs7574865 polymorphism is an effective marker of an increased risk of RA development in the population of the Republic of Belarus.
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