Association of serum matrix metalloproteinase-9 levels and C-reactive protein with peripheral vascular disease of lower limbs in type 2 diabetes mellitus

Abstract

Serum matrix metalloproteinase-9 (MMP-9), hypersensitive C-reactive protein (hsCRP) and other clinical parameters were measured in patients with types 2 diabetes mellitu (with or without angiopathy of lower limbs). The serum levels of MMP-9 and hsCRP were higher in type 2 diabetic patients and those with angiopathy by Doppler ultrasonography than those in normal controls. The change of serum MMP-9 was positively correlated with the level of hsCRP. The extent of angiopathy was correlated positively with both hsCRP and MMP-9. Key words: Matrix metalloproteinase-9; C-reactive protein; Diabetes mellitus, type 2; Angiopathy