Abstract
Objective To explore the association of serum liver enzymes with thyroid hormones and Chinese visceral adipose index (CVAI) in patients with type 2 diabetes mellitus (T2DM), and to evaluate the influencing factors of liver enzymes. Methods A total of 700 patients with T2DM were divided into elevated liver enzyme group and normal liver enzyme group, or three groups according to tertiles in alanine aminotransferase (ALT), aspartate aminotransferase (AST), and glutamyltransferase (GGT). The differences of thyroid hormones and CVAI among groups were compared, and the correlations of liver enzyme levels with thyroid hormones and CVAI were determined. Results Compared with the normal liver enzyme group, thyroxine(T4)and CVAI were increased in the elevated liver enzyme group (P<0.05). Free triiodothyroid (FT3), triiodothyroid (T3), and T4 levels were elevated with the increase of ALT and AST (P<0.05). CVAI was elevated with the increase of ALT and GGT (P<0.05). Correlation analysis showed that FT3, T3, and T4were positively correlated with ALT and AST. ALT and GGT were positively correlated with CVAI. CVAI was positively correlated with FT3 and T3. HbA1Cwas negatively correlated with FT3, T4, and T3. Regression analysis showed that FT3, CVAI, and HbA1C were the influencing factors for ALT, T4 was the influencing factor for AST, T3 and HbA1Cwere the influencing factors for GGT. Conclusions In patients with T2DM, thyroid hormones and CVAI are correlated with liver enzymes. Key words: Diabetes mellitus, type 2; Alanine aminotransferase; Aspartate aminotransferase; Glutamyltransferase; Thyroid hormones; Chinese visceral adipose index
Published Version
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